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While the rest of the world was completely unprepared to face the COVID outbreak, three countries — Taiwan, Hong Kong and Singapore — used their earlier experience with disease outbreaks to reduce the spread of the virus.

Dialogue on China, Hong Kong and the New Cold War

This suggests that it is possible to effectively contain the pandemic, even if you are situated close to China. These three countries have rapidly deployed testing, combined with digital surveillance, to trace infected individuals and have put in place strict quarantine for suspected cases. These measures, along with the build-up of large stockpiles of personal protective equipment, allowed them to fight back quickly.

The majority of other countries reached the stage of community transmission before adequate testing was in place, including decentralized, point-of-care testing. The RT-PCR system is very sensitive and can detect even very low amounts of virus from inside of the mouth or nose. However, the test protocol is very complex, involving sample collection, shipping to a central laboratory, RNA isolation and reverse transcription followed by quantitative PCR.

This protocol needs high-end laboratory infrastructure and logistics and has a high turnaround time of minimum of 1 to 2 days at best.

A similar test based on isothermal amplification-based technologies is under development for COVID diagnostics. The isothermal techniques include recombinase polymerase amplification, helicase-dependent amplification and loop-mediated isothermal amplification LAMP.

In this assay, the patient sample is added to the tube and the amplified DNA is detected by turbidity, color or fluorescence. The challenge with LAMP is that it requires a long time for optimizing primers and reaction conditions.

Immunoassays, on the other hand, can provide information about viral exposure and diagnostic evidence. Not all antibodies are the same or created at the same time during the infection.

IgG shows that someone has had the virus and is now protected from it. These limitations make immunoassays less reliable and sensitive. However, the latter is faster and delivers results within minutes. At a later stage, flow immunoassays can be mass manufactured and can be used by trained personnel. In case of this virus, the spike protein S facilitates entry of the pathogen into airway epithelial cells by binding to the angiotensin-converting enzyme 2 ACE2 expressed on these cells.

Companies like Neuome Technologies Pvt. These technologies will be able to directly measure actual viral particles in concentrations as low as 30 particles, in as little as minutes, and can be used on-the-spot. They will be similar to a pregnancy strip test, but will use a buccal swab or saliva for detection. This technology will help in identifying even asymptomatic individuals in the early stages of infections. As it does not need any instrument, it can be deployed even in remote areas, at ports of entry such as airportsfor soldiers, social gatherings, malls and other places.

Such integration of decentralised testing with epidemiological surveillance would go a long way in enabling public health authorities to reduce the spread of the infection. In an interaction with S Harachand, Prof Harding says that there is no need to wait until a patient is dying to introduce the benefits of palliative care, as integrating palliative care much earlier into the treatment cycle of a terminally ill patient will not only improve outcomes but can at times even prolong the life of the patient.

A strong critic of the traditional English British medical education system that is still followed in India, Dr G Richard Olds says that Indian medical education system has challenges on several fronts. The polygenic risk score for coronary artery disease, if implemented at the population level, would help in better stratification of high-risk individuals, says Dr Vedam Ramprasad, CEO, MedGenome Labs.

Dr Rajagopal is of the view when support is given to COVIDaffected people to make realistic, not idealistic choices, the disproportionate demand on irrational aggressive life support measures will drop and the health systems will be able to give optimal care to those who will benefit. Edited excerpts from his conversation with FM. Prof Mahendra K Verma from IIT-Kanpur, who led the study, warns that India, which exhibited linear growth and has now reached exponential growth, is yet to show a similar succession or signs of flattening the curve.The system will adopt international best practices without losing its alignment to existing local needs, it added.

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The CoE will provide scalable and affordable professional services to support joint customer digital transformations. The complexity traditionally involved with launching data and analytics use cases has been a significant barrier to widespread adoption. The fire at the Escravos-Lagos pipeline required a shutdown of the pipeline supplying gas to the 1,megawatt Egbin power plant.

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Devotional meals qualify as experiential dining and restaurants are looking at culinary experiences from other cultures too. On the building plan, there are 19 account management divisions on separate floors and creative planning divisions on various levels.

Have you read these stories? India crosses 2 crore mark in Covid doses Updated: Mar 07, The cumulative number of Covid vaccine doses administered in the country crossed 2. ET NOW. Brand Solutions. ET India Inc.

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ET Markets Conclave — Cryptocurrency. The Economic Times Startup Awards Reshape Tomorrow Tomorrow is different. Let's reshape it today. TomorrowMakers Let's get smarter about money. Corning Gorilla Glass TougherTogether. Great Manager Awards. Government implementing Rs crore project for 5 ports to enable digital ecosystem "An enterprise business system EBS is being implemented at five major ports with a project cost of about Rs crore to provide a digital port ecosystem," Ministry of Ports, Shipping and Waterways has said in a document.

Wastewater containing coronavirus may be potential threat, say scientists According to the review research, conventional wastewater treatment All News Videos Photos.

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Kiran Mazumdar-Shaw is a pioneering biotech entrepreneur, a healthcare visionary, a global influencer and a passionate philanthropist. Mazumdar-Shaw is the proud recipient of two of India's highest civilian honours, the Padma Shri and the Padma Bhushan Inshe was conferred with the highest French distinction - Knight of the Legion of Honour. He co-leads the GlobalMentalHealth Harvard initiative.

His work has focused on the burden of mental health problems, their association with social disadvantage, and the use of community resources for their prevention and treatment. For the past 30 years, she has conducted research on enteric infections in children and their consequences on growth and development.

In addition to generating insights into inflammation, intestinal function and the microbiome, she has evaluated a range of interventions from water treatment strategies to vaccination in clinical trials.

Her work is internationally recognized, and she serves on multiple advisory committees at the World Health Organisation, for philanthropic organisations and international institutions. A cardiac surgeon of repute and a successful entrepreneur, Devi Shetty is a highly respected luminary for his ingenious ideas for reforms in healthcare sector.

His visionary leadership to make quality healthcare affordable for all has drawn global recognition. He has worked along with the Government of India, state governments, trade bodies and global policy think tanks to develop vital healthcare policies. A strong advocate of technology for efficient healthcare delivery, Dr. Shetty takes deep interest in creating and developing software products and applications to achieve time and cost efficiency while minimizing clinical errors in healthcare delivery.

In association with Karnataka government he pioneered Yeshaswini, a very inexpensive micro health insurance scheme benefitting more than 3. In her 36 years of service as a civil servant, she spent 20 years in the health sector in different capacities at the state and federal levels. Currently, Ms. His work is focused on the design of national and regional health systems. Rajani R. She is a Visiting Scientist, Harvard T. Chan School of Public Health.

Her expertise spans policy development, implementation research; technical support to strengthen health systems, and design and evaluation of large-scale health programmes.Bangalore: Strand Scientific Intelligence of Strand Life Sciences Tuesday unveiled an image database for better diagnosis and treatment of cancer patients. Govt ready to amend new farm laws; opposition playing politics at cost of agri-economy: Tomar. Horoscope March 7: Aries will impress others with their good thoughts, know about your zodiac sign.

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High petrol, diesel prices burden on consumers; tax cut should be joint call of Centre, states: FM.

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Want to fly to moon?The national guidelines outline what encompasses gene therapy and GTPs. It brings new gene therapies under the umbrella of existing laws regulating drugs and medicinal practices in India — such as the Drug and Cosmetics Act, and the Drugs and Magical Remedies The Objectionable Advertisements Act, GTAEC will be composed of a core group of scientists and clinicians who have prior knowledge of gene therapy as evidenced by publications and participation in clinical trials of gene therapeutic products GTPas well as representation from government agencies.

Also read : GM babies are possible, but do we really want them? Such therapies provide a highly personalised, long-term cure for illnesses such as haemophilia, thalassemia, sickle-cell anaemia and certain forms of muscular dystrophies. At present, about 72 to 96 million people in India are expected to be affected by some form of rare disease. Under the new national guidelines, germ-line gene therapy remains prohibited in India.

The concept of germ-line gene therapy involves introduction of gene modified cells at the embryo stage. Somatic cell gene therapy is the only acceptable approach under the policy as it affects targeted cells or organs in the patient and is not passed on to subsequent generations.

He added that there is a huge global market for gene therapies, and biologists in our country have the capacity to address it. Rao, former senior advisor to DBT, Ministry of Science and Technology, said while the science of gene therapy has gone very far, the legislation governing it has not been keeping up. Also read : How Chinese scientists created monkeys with human brain genes. India needs free, fair, non-hyphenated and questioning journalism even more as it faces multiple crises.

But the news media is in a crisis of its own. There have been brutal layoffs and pay-cuts. The best of journalism is shrinking, yielding to crude prime-time spectacle. ThePrint has the finest young reporters, columnists and editors working for it. Sustaining journalism of this quality needs smart and thinking people like you to pay for it. Whether you live in India or overseas, you can do it here.

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Strand unveils image database for cancer cure

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Password recovery. Recover your password. Sunday, 7 March, Get help. Home Health Genetics labs come under watch, govt to monitor gene therapy research across An illustration of DNA strands pixabay.

India records 14, new Covid cases in past 24 hours, highest in 22 days. Share Your Views. Please enter your comment! Please enter your name here.

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You have entered an incorrect email address! Most Popular. All rights reserved.You are currently using the site but have requested a page in the site. Would you like to change to the site? Vijay ChandruJohn Hooker. Request permission to reuse content from this site. Wiley Series in Discrete Mathematics and Optimization.

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Genetics labs come under watch, govt to monitor gene therapy research across India

Merging logic and mathematics in deductive inference-an innovative, cutting-edge approach. Optimization methods for logical inference?

Absolutely, say Vijay Chandru and John Hooker, two major contributors to this rapidly expanding field. And even though "solving logical inference problems with optimization methods may seem a bit like eating sauerkraut with chopsticks. Requiring no background in logic and clearly explaining all topics from the ground up, Optimization Methods for Logical Inference is an invaluable guide for scientists and students in diverse fields, including operations research, computer science, artificial intelligence, decision support systems, and engineering.

JOHN N. Permissions Request permission to reuse content from this site. Table of contents Propositional Logic: Special Cases. Propositional Logic: The General Case. Probabilistic and Related Logics. Predicate Logic. Nonclassical and Many-Valued Logics. Reviews "Singh, Madalsa and Balachandra, P. Sharma, Tarun and Balachandra, P. Amrutha, A. Dash, N. Balachandra, P. Hiremath, R. Deepak, P. Ravindranath, Veilumutthu. Sudhakara Reddy, B. Ravindranath, N. Kumar, B.

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